Get the latest research information from NIH. The CTSA Program is designed to develop innovative solutions that will improve the efficiency, quality and impact of the process for turning observations in the laboratory, clinic and community into interventions that improve the health of individuals and the public.
Learn more. Researchers can view initiated projects in the N3C Data Enclave, including projects examining associations between COVID patient outcomes and social determinants of health. Turning scientific discoveries into clinical advances often is an inefficient process due to insufficient resources and too few specially trained researchers.
CTSA Program hubs collaborate locally, regionally and nationally, fostering innovation in training and research methodologies. NCATS continues to build on the strong foundation of the CTSA Program to tackle system-wide scientific and operational problems to make the clinical and translational research enterprise more efficient.
Multimedia Photos Videos Infographics. Translational Science Spectrum. Drug Discovery, Development and Deployment Maps. Translational Science Resources. Translational Science Skills. Assay Development and Screening Technology. Assay Guidance Manual. While developing the model, the students read an original research paper and come to understand that science is a process whereby real people -- not unlike themselves -- come to understand an invisible molecular mechanism.
The physical model that results from these modeling projects become useful communication tools that are used by the researchers to tell the story of their research to others. A gene expression signature sets of genes that are expected to be coordinately induced or repressed is used as input, and openSESAME returns a list of datasets in which these genes are coordinately differentially expressed, as well as plots heat maps of the expression of the signature genes in these datasets.
Profiles Research Networking Software is an NIH-funded open source tool to speed the process of finding researchers with specific areas of expertise for collaboration and professional networking.
Profiles RNS imports and analyzes "white pages" information, publications, and other data sources to create and maintain a complete searchable library of web-based electronic CVs. Built-in network analysis and data visualization tools allow administrators to generate research portfolios of their institution, discover connections between parts of their organization, and understand what factors influence collaboration. The main Registry goal is to aid investigators with recruitment and to promote a research-informed community of potential research participants.
The Registry also includes individuals from the general community in Western Pennsylvania who are matched with studies based upon their stated preference of health interests.
The goal of the Community Registry is to provide community members opportunities to receive educational materials about clinical research and to receive their permission to be contacted for study recruitment. CORES is a highly configurable, enterprise-wide software solution for research institutions which provides full central oversight while also allowing for flexible but consistent decentralized billing and usage functionality for core facilities. It has been available in the national community since approximately and grown steadily in its support of CTSA institutions since Science Exchange is a web-based platform to help researchers efficiently find and access research core facilities.
Since launching in August , Science Exchange has gained significant traction in the US with core facilities from over research institutes using the free platform to help get additional work and track usage of their facilities. The free software significantly reduces the administrative burden of managing core facilities and ensures payment from core facility users, reducing the amount of accounts receivable owed to facilities.
Please join the webinar to learn more about Science Exchange and help create a centralized portal for efficient access to research and core facilities. The Graduate Tracking Survey System GTSS , a web-based electronic questionnaire pre-populates the graduate's information on publications, clinical trials, grants, and patents by downloading the information in standardized format from public databases, which simplifies completion for graduates, insures a uniform format of important information, and facilitates aggregation of data.
The GTSS obtains information on whether trainees go on to improve human health, as well as related surrogate indicators of career development, and it is applicable to all training programs involving translational scientists.
When a graduate enters the web-based survey, she or he finds pre-populated fields for publications, grants, patents , and participation in clinical protocols, and need only confirm that the information from these sources is correct instead of entering the data manually.
If adopted broadly, the GTSS has the potential for aggregating standardized CTSA-wide data training for reporting to NIH and the public, providing benchmarks for assessing the success of individual training programs, and identifying opportunities to improve training programs. StudySearchTM is a web-based application designed to provide an easily readable publicly accessible searchable listing of IRB-approved protocols that are accruing study subjects.
Postings include basic descriptive information: study title, purpose of the study, eligibility criteria, and study personnel contact information. Studies are listed by one of two methods; one automated and one manual: 1.
Studies registered on ClinicalTrials. IRBshare aims to optimize human research protections through building trust, enhancing communication, and sharing best practices between IRBs nationwide.
Presently, and based on extensive input from the OHRP, IRBshare is pertinent to only new multi-site studies funded by the National Institutes of Health NIH and undergoing the initial round of reviews conducted by the respective participating IRBs, inclusive of amendments to the protocol occurring during this initial review period.
TIES Tissue Information Extraction System is an open-source, end-to-end system to de-identify, structure, code using controlled terminologies, and retrieve free-text pathology reports associated with bio-specimens. The tool enables users to query and analyze a large document repository, to use these documents to identify and obtain tissues for research, and to collaborate with other researchers.
The tool is built on a foundation of research compliance, and provides template processes and policies for deployment. NUCATS Assist has been used at Northwestern to run more than 30 internally sponsored competitions, including young investigator awards, shared resource awards, and foundation awards.
It is highly configurable and supports an NIH-style competition review process. PRISM supports the execution of multivariable prediction models with patient-specific characteristics so that personalized estimates of outcomes, often as a function of alternative treatments, can be generated within the routine flow of patient care. This can support evidence-based, shared medical decision-making to improve the safety, outcomes and cost-effectiveness of care.
The current application is in the setting of generating individualized informed consent documents for PCI. However, the tool can support that translation of novel biomarkers, genetics and pharmacogenomic interactions into clinical care. We have built a national research resource discovery platform that will help biomedical scientists search for and find previously invisible, but highly valuable, resources. Open network. Open access. Open source. After two years of intensive development, eagle-i is ready to leave the nest.
The free software is now an open source project, and we welcome institutions to adopt it and participate in the network. The data in the system is also now open access; anyone — regardless of affiliation — is welcome to sign up for an account, or to download the Linked Open Data directly.
Upgrades in process include work fulfillment data collection, invoicing and billing features, and outcome metrics using grant and publication data. It exists to reduce knowledge fragmentation and wasted effort. Groups can be created and managed easily, discussion threads can track any subject, and CTSA members can find and follow one another.
Reveal Connections. Realize Potential.
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